Portland-limestone cement (PLC) currently has gained widespread use as the most accessible and sustainable blended cement in the market. However, in many African countries, including Ghana, the use of clay pozzolana (CP) in the concrete industry has primarily relied on ordinary portland cement (OPC). In this study, PLC Type II/B-L was partially replaced with CP at levels ranging from 10 to 50% by weight. The investigation included compressive strength testing, nondestructive evaluations using electrical surface resistivity, pulse velocity, and chloride penetration tests, targeting a characteristic strength of 30 MPa (4351.13 psi). Additionally, an environmental impact assessment based on the carbon footprint of both control and CP concretes was conducted. The mixture design followed the EN 206 standard. A total of 72 cubic molds were produced for the strength test. The results showed that CP concretes with between 10 and 20% replacement achieved strength values of 35 and 33 MPa (5076.4 and 4786.32 psi), respectively, higher than the target of 30 MPa (4351.13 psi) strength at 28 days. However, mixtures with 30 to 50% replacement required extended curing periods of 60 to 90 days to reach the desired strength. At extended curing, 10 to 50% CP replacement attained strength between 32 and 41 MPa (4641.28 and 5946.64 psi). Nondestructive test results showed no direct correlation with compressive strength, confirming that different factors govern strength, resistivity, and pulse velocity. The environmental impact assessment revealed a 14 to 51% reduction in carbon strength index (CSi) and a 19 to 36% increase in carbon durability index (CRi) with 10 to 50% CP (for CSi) and 10 to 40% (for CRi). The thermodynamic modeling also revealed that pozzolana contents below 30% primarily promoted pozzolanic reactions, enhancing performance compared to the control mixture. Based on these results, 20 to 30% CP replacement is recommended to ensure reliable performance, while higher levels (>30%) require further durability evaluation for long-term use.