Climate change is a contemporaneous challenge with a projected increase of 1°C to 5°C in global temperature by the year 2100. With fossil fuel combustion, population growth and land use changes being the primary drivers, warming of the global, micro and indoors environments are certain. Warming is a major determinant of thermal comfort, energy used for mechanical cooling and greenhouse gas emissions. Data on thermal comfort in the Savannah Climatic zone of Ghana is not available. International research findings and standards exist but are not true reflections of the responses of people in the tropics. Local studies cited were conducted outside the climatic zone. Assessment of outdoor and indoor thermal comfort, subjective occupant comfort, and building envelope performance has not been done concurrently creating gaps in knowledge. The aim of the research is to assess the prevailing thermal comfort conditions of residential buildings in the Upper East Region in the Savannah Climatic Zone. To assess the levels of thermal stress of the ambient environment on the inhabitants as the first objective, RaymanPro software was used to derive Physiological Equivalent Temperature (PET) and Universal Thermal Climate Index (UTCI) values. Also to determine the frequency and severity of overheating of the indoor environment as the second objective, indoor air temperature with monthly threshold temperature derived from the ASHRAE 55-2017 adaptive equation. Furthermore, in evaluating the subjective occupant thermal comfort as the third objective, a longitudinal thermal sensation survey was conducted. Lastly, to simulate the optimal building envelope element details to reduce indoor overheating as the fourth objective, EnergyPlus 9.0.1 was used to simulate treatments of thermal mass increases, roof overhang extension and wall insulation on an existing building. The study area is the Bolgatanga Municipality and Gowri, Kunkua and Sabodaa communities in the Bongo District. Twelve single storey compound houses were purposively selected for thermal sensation survey. Monitoring of indoor air temperature and speed, and relative humidity was conducted by the use of Hobo U12-012 and Arno AVM 440. For the outdoors, air temperature, relative humidity, wind speed and global horizontal solar radiation was sourced from the West Africa Science Service Centre for Climate Change and Adapted Land Use (WASCAL) Eddy Covariant (EC) station in Sumbrungu. The study was carried out in the six warmest months of November and December of 2014, February, March, April and May of 2015. The results showed that the ambient thermal stress poses risk of ‘moderate’ to ‘extreme thermal’ stresses on the PET Scale. The indoor environment had exceedance and frequency of overheating above 56% and 38 degree hours. Also, 85% of the respondents accepted temperatures ranging from 25.5°C to 33°C with 30.3°C as neutral temperature. A combination of thermal mass, exterior wall insulation, roof extension generated a reduction of 18.5% in overheating. In contributing to knowledge, a more representative adaptive thermal sensation equation was established. Exceedance and severity of overheating procedure showed the challenges in its use in the tropics. The simulation of treatments on building envelope provides reference points for future simulation studies.